abstract：:Guidelines for the treatment of severe bleeding comprise viscoelastic-test-guided use of coagulation factor concentrates as part of their recommendations. The aim of this study is to investigate the effects of substituting fibrinogen, prothrombin complex concentrate, and a combination of both on conventional coagulati...

journal_title：Journal of clinical medicine

authors： Gratz J,Schlimp CJ,Honickel M,Hochhausen N,Schöchl H,Grottke O

更新日期：2020-11-25 00:00:00

abstract：:The ultrasound (US) pattern of intrathyroidal ectopic thymus (IET) can resemble papillary thyroid carcinoma (PTC) while the extrathyroidal ectopic thymus (EET) can mimic pathological lymph nodes. Recently, the usefulness of strain elastography (SE) was demonstrated in the differential diagnosis, however this method ha...

journal_title：Journal of clinical medicine

authors： Stasiak M,Adamczewski Z,Stawerska R,Stasiak B,Lewiński A

更新日期：2020-11-25 00:00:00

abstract：:Primary Sjögren's Syndrome (pSS) is an autoimmune disease mainly affecting salivary and lacrimal glands. Previous pSS studies have relied on primary cell culture models or cancer cell lines with limited relevance to the disease. Our objective was to generate and characterize immortalized salivary gland epithelial cell...

journal_title：Journal of clinical medicine

authors： Noll BD,Grdzelishvili A,Brennan MT,Mougeot FB,Mougeot JC

更新日期：2020-11-25 00:00:00

abstract：:An elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determine the relationship...

journal_title：Journal of clinical medicine

authors： Takaeko Y,Kajikawa M,Kishimoto S,Yamaji T,Harada T,Han Y,Kihara Y,Hida E,Chayama K,Goto C,Aibara Y,Yusoff FM,Maruhashi T,Nakashima A,Higashi Y

更新日期：2020-11-24 00:00:00

abstract：:The purpose of this study was to investigate the effect of high molecular weight hyaluronan (HMWHA) eye drops on subbasal corneal nerves in patients suffering from severe dry eye disease (DED) and to evaluate the damage of subbasal corneal nerves associated with severe DED. Designed as an international, multicenter st...

journal_title：Journal of clinical medicine

authors： van Setten GB,Stachs O,Dupas B,Turhan SA,Seitz B,Reitsamer H,Winter K,Horwath-Winter J,Guthoff RF,Müller-Lierheim WGK

更新日期：2020-11-24 00:00:00

abstract：:We aimed to examine the usefulness of serum glutathione peroxidase 3 (GPx3) as a biomarker of lung cancer recurrence after complete resection. We prospectively collected serial serum samples at the baseline, as well as 3, 6 and 12 months after surgery from complete resection cases in 2013. GPx3 levels were measured by...

journal_title：Journal of clinical medicine

authors： Kho BG,Park HY,Cho HJ,Park CK,Kim YC,Yun JS,Song SY,Na KJ,Choi YD,Lee SW,Oh IJ

更新日期：2020-11-24 00:00:00

abstract：:Low skeletal muscle mass (LSMM) is increasingly recognized for its predictive value for adverse events in cancer patients. In specific, the predictive value of LSMM has been demonstrated for anti-cancer drug toxicity in a variety of cancer types and anti-cancer drugs. However, due to the limited sample size and study ...

journal_title：Journal of clinical medicine

authors： Huiskamp LFJ,Chargi N,Devriese LA,May AM,Huitema ADR,de Bree R

更新日期：2020-11-23 00:00:00

abstract：:Most studies on well-being during the COVID-19 pandemic have focused on the mental health of the general population; far less attention has been given to more specific populations, such as patients with mental illness. Indeed, it is important to examine the psychiatric population, given its vulnerability. The present ...

journal_title：Journal of clinical medicine

authors： Burrai J,Roma P,Barchielli B,Biondi S,Cordellieri P,Fraschetti A,Pizzimenti A,Mazza C,Ferracuti S,Giannini AM

更新日期：2020-11-23 00:00:00

abstract：:Because of limitations caused by unique complications of free flap reconstruction, the Clavien-Dindo classification was modified to include grade "IIIc" for "partial or total free flap failure." From 2013 to 2018, 116 patients who had undergone free flap reconstruction for head and neck cancer with grade III or higher...

journal_title：Journal of clinical medicine

authors： Jan WL,Chen HC,Chang CC,Chen HH,Shih PK,Huang TC

更新日期：2020-11-22 00:00:00

abstract：:Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, ca...

journal_title：Journal of clinical medicine

authors： Koumpis E,Florentin M,Hatzimichael E,Liamis G

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:This study aimed to investigate the outcome of therapeutic penetrating keratoplasty (TPK) for medically-uncontrolled infectious keratitis, and to determine the factors associated with the recurrence of infection after TPK. METHODS:A 10-year retrospective study of medically-uncontrolled infectious keratitis ...

journal_title：Journal of clinical medicine

authors： Moon J,Yoon CH,Kim MK,Oh JY

更新日期：2020-11-18 00:00:00

abstract：:After normal survival has been achieved in most patients with chronic myeloid leukemia (CML), a new goal for treating CML is survival at good quality of life, with treatment discontinuation in sustained deep molecular response (DMR; MR4 or deeper) and treatment-free remission (TFR). Four tyrosine kinase inhibitors (TK...

journal_title：Journal of clinical medicine

authors： Hehlmann R

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Bioelectrical impedance analysis (BIA) is a simple and rapid technique to measure body composition (BC). Validity of BIA in patients with low body mass index (BMI) remains controversial. We assessed the validity of several BIA equations to evaluate fat-free mass (FFM), fat mass (FM) and muscle mass in patien...

journal_title：Journal of clinical medicine

authors： Coëffier M,Gâté M,Rimbert A,Petit A,Folope V,Grigioni S,Déchelotte P,Achamrah N

更新日期：2020-11-14 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...

journal_title：Journal of clinical medicine

authors： Mitsuyama K,Tsuruta K,Takedatsu H,Yoshioka S,Morita M,Niwa M,Matsumoto S

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Asthma patterns are not well established in epidemiological studies. AIM:To assess asthma patterns and risk factors in an adult general population sample. METHODS:In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011-2014). Latent transitio...

journal_title：Journal of clinical medicine

authors： Maio S,Baldacci S,Simoni M,Angino A,La Grutta S,Muggeo V,Fasola S,Viegi G,On Behalf Of The Agave Pisa Group

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:In hemodialysis patients, extracellular water (ECW) overload predicts all-cause and cardiovascular mortality. The primary aim of the present study was to analyze changes in post-dialysis (i.e., following removal of excess ECW) ECW, intracellular water (ICW), and the overhydration (OH) parameter over time. Ad...

journal_title：Journal of clinical medicine

authors： Gracia-Iguacel C,González-Parra E,Mahillo I,Ortiz A

更新日期：2020-11-10 00:00:00

abstract：:The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota in 46 ...

journal_title：Journal of clinical medicine

authors： Di Paola M,Seravalli V,Paccosi S,Linari C,Parenti A,De Filippo C,Tanturli M,Vitali F,Torcia MG,Di Tommaso M

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:The American Indian Navajo and Goshute peoples are underserved patient populations residing in the Four Corners area of the United States and Ibupah, Utah, respectively. METHODS:We conducted a cross-sectional study of epidemiological factors and lipid biomarkers that may be associated with type II diabetes,...

journal_title：Journal of clinical medicine

authors： Hicks PM,Haaland B,Feehan M,Crandall AS,Pettey JH,Nuttall E,Self W,Hartnett ME,Bernstein P,Vitale A,Shakoor A,Shulman JP,Sieminski SF,Kim I,Owen LA,Murtaugh MA,Noyes A,DeAngelis MM

更新日期：2020-11-07 00:00:00

abstract：:Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial transition could be considered as a sign of restored epithelial funct...

journal_title：Journal of clinical medicine

authors： Pedrotti E,Chierego C,Cozzini T,Merz T,Lagali N,De Gregorio A,Fasolo A,Bonacci E,Bonetto J,Marchini G

更新日期：2020-11-06 00:00:00

abstract：BACKGROUND:As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients' perceptions of dyspnea and their COPD living disabilities remains a major challenge. ...

journal_title：Journal of clinical medicine

authors： Oishi K,Matsunaga K,Harada M,Suizu J,Murakawa K,Chikumoto A,Ohteru Y,Matsuda K,Uehara S,Hamada K,Ohata S,Murata Y,Yamaji Y,Asami-Noyama M,Edakuni N,Kakugawa T,Hirano T

更新日期：2020-11-06 00:00:00

abstract：:Chronic pain is one of the major causes of disability in the general population. Even though there are effective treatment options available for reducing symptoms, these treatments often do not have consistent lasting effects. As the usage of mobile devices has increased enormously during the last few years, mobile ap...

journal_title：Journal of clinical medicine

authors： Pfeifer AC,Uddin R,Schröder-Pfeifer P,Holl F,Swoboda W,Schiltenwolf M

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Co-prescribing medications that can interact with direct-acting oral anticoagulants (DOACs) may decrease their safety and efficacy. The aim of this study was to examine the co-prescribing of such medications with DOACs using the Australian national general practice dataset, MedicineInsight, over a five-year ...

journal_title：Journal of clinical medicine

authors： Bezabhe WM,Bereznicki LR,Radford J,Wimmer BC,Salahudeen MS,Bindoff I,Garrahy E,Peterson GM

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...

journal_title：Journal of clinical medicine

authors： Limeres J,Serrano C,De Nova JM,Silvestre-Rangil J,Machuca G,Maura I,Cruz Ruiz-Villandiego J,Diz P,Blanco-Lago R,Nevado J,Diniz-Freitas M

更新日期：2020-11-04 00:00:00

abstract：:Both pre-gestational maternal obesity (PGMO) and excessive gestational weight gain (EGWG) increase the risk of gestational diabetes mellitus (GDM). Here, we conducted a retrospective study to comparatively examine the relation between fetal birth weight (FW) and placental weight (PW) in PGMO (n = 100) compared to EGWG...

journal_title：Journal of clinical medicine

authors： Gujski M,Szukiewicz D,Chołuj M,Sawicki W,Bojar I

更新日期：2020-10-31 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) is a disease that affects the jaw. It is mainly related to radiation or bisphosphonates therapy, and the symptoms and signs consist of pain, bone exposure, inflammation of the surrounding soft tissue swelling, and secondary infection or drainage. In the case of advanced disease of the ma...

journal_title：Journal of clinical medicine

authors： Ricotta F,Battaglia S,Bolognesi F,Ceccariglia F,Marchetti C,Tarsitano A

更新日期：2020-10-30 00:00:00

abstract：:Despite the increasing incidence of gastroesophageal junction adenocarcinoma (GEJA), the optimal treatment strategy for the disease remains unknown. The objective of this study was to describe treatment patterns for GEJA in the United States. The National Cancer Database was searched to identify all patients who under...

journal_title：Journal of clinical medicine

authors： Kim BJ,Chiang YJ,Das P,Minsky BD,Blum MA,Ajani JA,Estrella JS,Hofstetter WL,Tzeng CD,Badgwell BD,Mansfield PF,Ikoma N

更新日期：2020-10-29 00:00:00

abstract：:Radiation chorioretinopathy, radiation maculopathy, and radiation optic neuropathy are the major complications of ophthalmic radiotherapy. Optical coherence tomography (OCT) and OCT angiography (OCTA) are revolutionary imaging methods, allowing the visualization of the retinal cellular architecture and the retinal vas...

journal_title：Journal of clinical medicine

authors： Midena G,Parrozzani R,Frizziero L,Midena E

更新日期：2020-10-29 00:00:00

abstract：:Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and...

journal_title：Journal of clinical medicine

authors： Barbeta E,Ceccato A,Artigas A,Ferrer M,Fernández L,López R,Bueno L,Motos A,Bassi GL,Mellado R,Ferrando C,Palomeque AC,Panigada M,Gabarrús A,de Mendoza D,Torres A

更新日期：2020-10-29 00:00:00

abstract：BACKGROUND:Due to its unknown etiology, the objective diagnosis and therapeutics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are still challenging. Generally, the patient-reported outcome (PRO) is the major strategy driving treatment response because the patient is the most important judge of whether...

journal_title：Journal of clinical medicine

authors： Kim DY,Lee JS,Son CG

更新日期：2020-10-28 00:00:00

abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...

journal_title：Journal of clinical medicine

authors： Bergh EP,Tsao K,Austin MT,Fletcher SA,Lopez SM,Moise KJ Jr,Johnson A,Papanna R

更新日期：2020-10-27 00:00:00

abstract：:Pediatric cancer survivors are at increased risk for psychological distress. We sought to understand the severity and symptoms' co-occurrence among pediatric survivors compared to controls by rating both self- and parent-reported symptomatology. Forty survivors (22 males; mean age at study time: 12.9 years) participat...

journal_title：Journal of clinical medicine

authors： Barone R,Gulisano M,Cannata E,Padalino S,Saia F,Maugeri N,Pettinato F,Lo Nigro L,Casabona A,Russo G,Di Cataldo A,Rizzo R

更新日期：2020-10-27 00:00:00

abstract：INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this s...

journal_title：Journal of clinical medicine

authors： Wilczyńska K,Waszkiewicz N

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Or...

journal_title：Journal of clinical medicine

authors： Hong SK,Yi NJ,Yoon KC,Kim MS,Lee JG,Lee S,Kang KJ,Hwang S,Ryu JH,Hong K,Han ES,Lee JM,Lee KW,Suh KS

更新日期：2020-10-26 00:00:00

abstract：:The limited number of available studies that examined the pathology of alcohol hangover focused on biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to alcohol as potentially important determinants of hangover severity. The available literature on alcohol metabolism and oxidative stress ...

journal_title：Journal of clinical medicine

authors： Mackus M,Loo AJV,Garssen J,Kraneveld AD,Scholey A,Verster JC

更新日期：2020-10-25 00:00:00

abstract：:An increasing number of patients with coronary artery disease are at high operative risk due to advanced age, severe comorbidities, complex coronary anatomy, and reduced ejection fraction. Consequently, these high-risk patients are often offered percutaneous coronary intervention (PCI) as an alternative to coronary ar...

journal_title：Journal of clinical medicine

authors： Johannsen L,Soldat J,Krueger A,Mahabadi AA,Dykun I,Totzeck M,Jánosi RA,Rassaf T,Al-Rashid F

更新日期：2020-10-25 00:00:00

abstract：:The incidence of melanoma has been increasing worldwide during recent decades. The objective of the study was to analyse the trends in incidence for in situ and invasive melanoma in the Spanish region of Catalonia during the period of 2008-2017. We designed a cross-sectional study with an age-period-cohort analysis of...

journal_title：Journal of clinical medicine

authors： Podlipnik S,Carrera C,Boada A,Richarz N,Marcoval J,Ferreres JR,Bodet D,Martí RM,Segura S,Sabat M,Dalmau J,Quintana M,Azon A,Curcó N,Formigon M,Olivella-Garcés MR,Zaballos P,Sola J,Galvany L,Baliu-Piqué C,Alegre M

更新日期：2020-10-23 00:00:00

abstract：:The pathophysiology of cardiogenic shock (CS) varies depending on its etiology, which may lead to different hemodynamic profiles (HP) and may help tailor therapy. We aimed to assess the HP of CS patients according to their etiologies of acute myocardial infarction (AMI) and acute decompensated chronic heart failure (A...

journal_title：Journal of clinical medicine

authors： Gaubert M,Laine M,Resseguier N,Aissaoui N,Puymirat E,Lemesle G,Michelet P,Hraiech S,Lévy B,Delmas C,Bonello L

更新日期：2020-10-22 00:00:00

abstract：:Dilated Cardiomyopathy (DCM) has a straightforward and apparently "simple" definition: a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfun...

journal_title：Journal of clinical medicine

authors： Merlo M,Cannatà A,Sinagra G

更新日期：2020-10-22 00:00:00

abstract：INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...

journal_title：Journal of clinical medicine

authors： Bösch F,Altendorf-Hofmann A,Jacob S,Auernhammer CJ,Spitzweg C,Boeck S,Schubert-Fritschle G,Werner J,Kirchner T,Angele MK,Knösel T

更新日期：2020-10-21 00:00:00

abstract：:Partial ruptures in the Achilles tendon are rather uncommon and are often misinterpreted as aggravated Achilles tendinopathy, and not always considered as a differential diagnosis. The aim of this literature review was to characterize typical symptoms, to provide an overview of available diagnosis and treatment option...

journal_title：Journal of clinical medicine

authors： Gatz M,Spang C,Alfredson H

更新日期：2020-10-21 00:00:00